Triethylamine → HCID 86597899, compound

Reaction equation

[NH2:1][C@H:2]([C:15]([NH:17][C:18]1[CH:19]=[N:20][N:21]([CH3:24])[C:22]=1[NH2:23])=[O:16])[CH2:3][CH2:4][CH2:5][CH2:6][NH:7][C:8](=[O:14])[O:9][C:10]([CH3:13])([CH3:12])[CH3:11].C(N(CC)CC)C.[C:32]([O:36][C:37]([NH:39][CH2:40][CH2:41][C:42](ON1C(=O)CCC1=O)=[O:43])=[O:38])([CH3:35])([CH3:34])[CH3:33]>C(Cl)(Cl)Cl>[NH2:23][C:22]1[N:21]([CH3:24])[N:20]=[CH:19][C:18]=1[NH:17][C:15](=[O:16])[C@@H:2]([NH:1][C:42](=[O:43])[CH2:41][CH2:40][NH:39][C:37]([O:36][C:32]([CH3:34])([CH3:33])[CH3:35])=[O:38])[CH2:3][CH2:4][CH2:5][CH2:6][NH:7][C:8](=[O:14])[O:9][C:10]([CH3:13])([CH3:12])[CH3:11]

Participants

Procedure

To a solution of tert-butyl (5S)-5-amino-6-[(5-amino-1-methyl-1H-pyrazol-4-yl)amino]-6-oxohexylcarbamate (1.60 g) and triethylamine (0.47 g) in chloroform (100 ml) was added N-[3-(tert-butoxycarbonylamino)propionyloxy]succinimide (1.34 g). The mixture was stirred at room temperature for 15 hours. The mixture was washed with saturated aqueous sodium hydrogencarbonate solution. The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated in vacuo to give a crude product of tert-butyl (5S)-6-[(5-amino-1-methyl-1H-pyrazol-4-yl)amino]-5-{[3-(tert-butoxycarbonylamino)propionyl]amino}-6-oxohexylcarbamate (2.09 g) as an oil. The crude product was used directly in the next step without further purification.