Acetic acid 3-benzyloxycarbonylamino-4-oxo-azetidin-2-yl ester → Acetic acid 3-amino-4-oxo-azetidin-2-yl ester
Reaction equation
C(OC([NH:11][CH:12]1[C:15](=[O:16])[NH:14][CH:13]1[O:17][C:18](=[O:20])[CH3:19])=O)C1C=CC=CC=1>[Pd].C(OCC)(=O)C>[NH2:11][CH:12]1[C:15](=[O:16])[NH:14][CH:13]1[O:17][C:18](=[O:20])[CH3:19]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
Acetic acid 3-benzyloxycarbonylamino-4-oxo-azetidin-2-yl ester (100 mg, 0.36 mmol) was hydrogenated on a Parr shaker over 10% palladium on carbon (100 mg) in ethyl acetate (20 ml) at 50 psi for 5 h. The mixture was filtered through Celite and evaporated. Acetic acid 3-amino-4-oxo-azetidin-2-yl ester was obtained in quantitative yield.
Workup
- filtrationThe mixture was filtered through Celite
- customevaporated
Sources & evidence
- ORD record
- ord-3cfe61c790c5448d851567369623ad4d
- Source dataset
- uspto-grants-2007_03
- Patent number
- US07196099B2
Reaction notes
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