[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8](Cl)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[OH:12][CH2:13][CH2:14][CH2:15][C:16]1([CH3:23])[NH:20][C:19](=[O:21])[NH:18][C:17]1=[O:22].C(Cl)(Cl)Cl>N1C=CC=CC=1.O>[CH3:23][C:16]1([CH2:15][CH2:14][CH2:13][O:12][S:8]([C:5]2[CH:6]=[CH:7][C:2]([CH3:1])=[CH:3][CH:4]=2)(=[O:10])=[O:9])[NH:20][C:19](=[O:21])[NH:18][C:17]1=[O:22]P-toluenesulfonyl chloride (22.5 g., 0.118 mol) was added to a stirred solution of 5-(3-hydroxypropyl)-5-methyl-2,4-imidazolidine-dione (20.0 g, 0.116 mol) in pyridine (250 ml.) at 5° C. The mixture was stirred for one hour, refrigerated overnight and diluted with water (275 ml.) The resulting solution was extracted three times with chloroform (375, 190 and 190 ml.), the combined extracts were washed with 5 N aqueous sulfuric acid (4 × 125 ml.), water (2 × 150 ml.) and saturated aqueous sodium bicarbonate solution (2 × 125 ml). Concentration of the dried chloroform phase yielded 5-methyl-5- {3-[(4-methylphenyl)sulfonyloxy]-propyl}-2,4-imidazolinedione (22.2 g., 0.068 mol, 58%) upon addition of ether and petroleum ether, m.p. 126-127° C.
Loading…
