2-(Methylamino)ethanol → 2-{2-[N-(2-Hydroxyethyl)methylamino]-5-thiadiazolyl}-1-methyl-5-nitroimidazole

HRID 462233

Reaction equation

HRID 462233 reaction equation
[N:1]1([N:7]2[NH:11][CH:10]=[C:9]([C:12]3[N:13]([CH3:20])[C:14]([N+:17]([O-:19])=[O:18])=[CH:15][N:16]=3)[S:8]2)[CH2:6]CC[CH2:3][CH2:2]1.CNCC[OH:25].N1CCCCC1>>[OH:25][CH2:3][CH2:2][N:1]([CH3:6])[N:7]1[NH:11][CH:10]=[C:9]([C:12]2[N:13]([CH3:20])[C:14]([N+:17]([O-:19])=[O:18])=[CH:15][N:16]=2)[S:8]1

Participants

4

Reactant 3

HCID 80162-(Methylamino)ethanolHCID 8082PiperidineHCID 213908372-(2-Piperidino-5-thiadiazolyl)-1-methyl-5-nitroimidazole

Product 1

HCID 681187562-{2-[N-(2-Hydroxyethyl)methylamino]-5-thiadiazolyl}-1-methyl-5-nitroimidazole

Procedure

The preparation of the above compound is carried out essentially as described for the 2-piperidino derivative (Example 28), an equivalent of N-methylethanolamine replacing the piperidine. The pure compound melts at 158°-160° C. after recrystallization from methanol.

Workup

  1. customThe preparation of the above compound
  2. customThe pure compound melts at 158°-160° C. after recrystallization from methanol

Sources & evidence

ORD record
ord-da559262e11a4cd4991ae08c78971761
Source dataset
uspto-grants-1977_12
Patent number
US04065567

Linked notes

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