2-Aminoheptane → 1-sec-heptyl-3-n-hexyl-2-S-ethylisothiourea

HRID 462476

Reaction equation

HRID 462476 reaction equation
[CH2:1]([N:7]=[C:8]=[S:9])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[NH2:10][CH:11]([CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])[CH3:12].[CH2:18](I)[CH3:19].[OH-].[Na+]>C1(C)C=CC=CC=1.C(O)C>[CH:11]([NH:10][C:8](=[N:7][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH3:6])[S:9][CH2:18][CH3:19])([CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])[CH3:12]

Participants

7

Reactant 4

HCID 56032-AminoheptaneHCID 6340IodoethaneHCID 14798Sodium HydroxideHCID 78120Hexyl isothiocyanate

Product 1

HCID 130834661-sec-heptyl-3-n-hexyl-2-S-ethylisothiourea

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 1140TolueneSolvent

Procedure

The equipment, procedure and reactants were the same as in Example 31 with the exception that 10.01 g (0.07 mole) of n-hexylisothiocyanate, 8.05 g (0.07 mole) 2-aminoheptane, 35 ml ethanol 2B, 11.7 g (0.075 mole) ethyl iodide, 200 ml of toluene and a one percent solution sodium hydroxide (0.08 mole) were used as reactants and reagents in the procedure. The reaction produced 19.6 g (98 weight percent of theory yield of a clear liquid having a nD30 of 1.4765. The product was identified as the title product by IR and NMR spectra analyses.

Workup

  1. customThe reaction produced 19.6 g (98 weight percent of theory yield of a clear liquid

Sources & evidence

ORD record
ord-eb18b9da3bd24229821e66ed16e08c60
Source dataset
uspto-grants-1985_05
Patent number
US04515813

Linked notes

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