Piperazine → 8-Methylamino-4-(1-oxido-thiomorpholino)-2-piperazino-pyrimido-[5,4-d]-pyrimidine

HRID 462991

Reaction equation

HRID 462991 reaction equation
Cl[C:2]1[N:3]=[C:4]([N:14]2[CH2:19][CH2:18][S:17](=[O:20])[CH2:16][CH2:15]2)[C:5]2[N:11]=[CH:10][N:9]=[C:8]([NH:12][CH3:13])[C:6]=2[N:7]=1.[NH:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>ClC1N=C(N2CCS(=O)CC2)C2N=CN=C(Cl)C=2N=1>[CH3:13][NH:12][C:8]1[C:6]2[N:7]=[C:2]([N:21]3[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]3)[N:3]=[C:4]([N:14]3[CH2:19][CH2:18][S:17](=[O:20])[CH2:16][CH2:15]3)[C:5]=2[N:11]=[CH:10][N:9]=1

Participants

4

Reactant 2

HCID 4837PiperazineHCID 128169982-Chloro-8-methylamino-4-(1-oxido-thiomorpholino)-pyrimido-[5,4-d]-pyrimidine

Product 1

HCID 128170548-Methylamino-4-(1-oxido-thiomorpholino)-2-piperazino-pyrimido-[5,4-d]-pyrimidine

Reagents, catalysts & solvents 1

HCID 128169922,8-Dichloro-4-(1-oxido-thiomorpholino)-pyrimido[5,4-d]pyrimidineSolvent

Procedure

This compound was prepared analogous to Example 118 from 2-chloro-8-methylamino-4-(1-oxido-thiomorpholino)-pyrimido-[5,4-d]-pyrimidine (m.p.: 278°-280° C.) and piperazine in dioxane at 80° C.

Sources & evidence

ORD record
ord-b9b3eae886db448c838979cb3fe07df0
Source dataset
uspto-grants-1985_05
Patent number
US04518596

Linked notes

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