Methyl iodide → 2-(1-Benzofuran-5-yl)ethan-1-ol

Reaction equation

Br[C:2]1[CH:10]=[CH:9][C:5]2[O:6][CH:7]=[CH:8][C:4]=2[CH:3]=1.CI.[Mg].[CH2:14]1[O:16][CH2:15]1>>[OH:16][CH2:15][CH2:14][C:2]1[CH:10]=[CH:9][C:5]2[O:6][CH:7]=[CH:8][C:4]=2[CH:3]=1

Participants

Reactant 4

HCID 6328Methyl iodide

HCID 6354Ethylene Oxide

HCID 90015Benzofuran, 5-bromo-

HCID 5462224Magnesium

Product 1

HCID 202650422-(1-Benzofuran-5-yl)ethan-1-ol

Procedure

The subject compound is prepared by a Grignard reaction with the reagant prepared from 5-bromobenzo[b]furan, methyl iodide and magnesium turnings and ethylene oxide.

Workup

customThe subject compound is prepared by a Grignard reaction with the

Sources & evidence

ORD record: ord-72170a2c379447f3aabaa7bc0ac5c8ae
Source dataset: uspto-grants-1985_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04544667

Reaction notes

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