6-(2,2,2-Trifluoroethoxy)pyridin-3-amine → 1-(2,6-Dichlorobenzoyl)-3-(6-(2,2,2-Trifluoroethoxy)-3-Pyridinyl)Urea
Reaction equation
[F:1][C:2]([F:13])([F:12])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[CH:7][N:6]=1.[Cl:14][C:15]1[CH:25]=[CH:24][CH:23]=[C:22]([Cl:26])[C:16]=1[C:17]([N:19]=[C:20]=[O:21])=[O:18]>C(OCC)(=O)C>[Cl:14][C:15]1[CH:25]=[CH:24][CH:23]=[C:22]([Cl:26])[C:16]=1[C:17]([NH:19][C:20]([NH:11][C:8]1[CH:7]=[N:6][C:5]([O:4][CH2:3][C:2]([F:1])([F:12])[F:13])=[CH:10][CH:9]=1)=[O:21])=[O:18]Participants
4
Procedure
2-(2,2,2-Trifluoroethoxy)-5-aminopyridine (0.5 gram) and 2,6-dichlorobenzoyl isocyanate (0.5 gram) were mixed in ethyl acetate, and the reaction mixture stirred overnight (about 18 hours) at room temperature. Solvent was removed by evaporation and the product residue crystallized from ethyl acetate-hexanes, yield 0.6 gram, m.p., 146°-148° C.