Dimethylamine → 1,3-Dihydro-1-[4-(dimethylamino)-2-butynyl]-3-methyl-2H-imidazol-2-one

Reaction equation

[CH3:1][N:2]1[CH2:6][CH2:5][N:4]([CH2:7][C:8]#[CH:9])[C:3]1=[O:10].[CH3:11][NH:12][CH3:13].N1CCC[CH2:15]1>>[CH3:11][N:12]([CH3:15])[CH2:13][C:9]#[C:8][CH2:7][N:4]1[CH:5]=[CH:6][N:2]([CH3:1])[C:3]1=[O:10]

Participants

Reactant 3

HCID 674Dimethylamine

HCID 31268Pyrrolidine

HCID 113555131-Methyl-3-(2-propynyl)-2-imidazolidinone

Product 1

HCID 150655181,3-Dihydro-1-[4-(dimethylamino)-2-butynyl]-3-methyl-2H-imidazol-2-one

Procedure

This product, a liquid, was prepared according to Example 1, Part B by substituting 1,3-dihydro-1-methyl-3-(2-propynyl)-2H-imidazol-2-one for 1-methyl-3-(2-propynyl)-2-imidazolidinone and dimethylamine for pyrrolidine.

Workup

customThis product, a liquid, was prepared

Sources & evidence

ORD record: ord-996ae39367a94d188f650901964b2237
Source dataset: uspto-grants-1992_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05157124

Reaction notes

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