Reaction equation
[N:1]12[CH2:7][C:5]([C:8]([NH2:10])=[O:9])([CH2:6]1)[CH2:4][CH2:3][CH2:2]2.[C:11]1(=O)[O:15][CH:14]=[CH:13][O:12]1.[C:17](=[O:20])([O-:19])[O-].[K+].[K+]>>[C:11]([OH:15])(=[O:12])[C:17]([OH:19])=[O:20].[O:9]1[CH:14]=[CH:13][N:10]=[C:8]1[C:5]12[CH2:7][N:1]([CH2:6]1)[CH2:2][CH2:3][CH2:4]2Participants
Conditions
- Temperature
- 120 °C
Procedure
A well stirred mixture of 1-azabicyclo[3.1.1]hept-5-ylcarboxamide (D12, 640 mg, 0.0046 mole) and vinylene carbonate (600 mg, 0.0069 mole) in polyphosphoric acid (25 g) was heated at 120° C. for 1 h. The hot solution was then poured cautiously, with good stirring, into excess potassium carbonate solution. The aqueous mixture was saturated with potassium carbonate and extracted with ethyl acetate (1×100 ml), followed by chloroform (1×100 ml). The combined extracts were dried (Na2SO4) and concentrated in vacuo at room temperature. The residue was immediately chromatographed on basic alumina eluting initially with ethyl acetate, increasing to 15% methanol/ethyl acetate to give a colourless oil (60 mg). This was converted to its oxalate salt and recrystallised from methanol/ether to give the title compound (E4) as a white solid (65 mg, 6%) m.p. 165°-166° C.
Workup
- extractionextracted with ethyl acetate (1×100 ml)
- dry with materialThe combined extracts were dried (Na2SO4)
- concentrationconcentrated in vacuo at room temperature
- customThe residue was immediately chromatographed on basic alumina eluting initially with ethyl acetate
- temperatureincreasing to 15% methanol/ethyl acetate
Sources & evidence
- ORD record
- ord-f7306b3e19a547bb8a3bbe1912694ec3
- Source dataset
- uspto-grants-1992_10
- Patent number
- US05157160
Linked notes
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