Tetrahydrofuran → 4-Phenylbut-3-en-2-ol

HRID 467283Notes

Reaction equation

HRID 467283 reaction equation
[CH:1](=[CH:8][C:9](=[O:11])[CH3:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C1C=CC(P(C2C=CC3C(=CC=CC=3)C=2C2C3C(=CC=CC=3)C=CC=2P(C2C=CC=CC=2)C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.F[B-](F)(F)F.O1CCCC1>CO>[C:2]1([CH:1]=[CH:8][CH:9]([OH:11])[CH3:10])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 8028TetrahydrofuranHCID 159094-Phenyl-3-Buten-2-oneHCID 26255TetrafluoroborateHCID 634876Binap, (A+-)-

Product 1

HCID 151724-Phenylbut-3-en-2-olYield 34.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In a 200 ml stainless steel autoclave were charged 5 g (34.2 mmole) of benzalacetone and 0.213 g (0.171 mmole) of ##STR24## ((+)-BINAP)}BF4 synthesized in Example 4, and 3 ml of tetrahydrofuran and 2 ml of methanol were added thereto, followed by allowing the mixture to react at 30° C. under a hydrogen pressure of 50 kg/cm2 for 45 hours. The solvent was removed by distillation under reduced pressure (10 mmHg), and the reaction product was analyzed by GLC (PEG HT, 25 m, produced by Gasukuro Kogyo K. K.) to find the conversion to be 34.5%. The product was separated into the unreacted ketone and the hydrogenation product by silica gel column chromatography (eluent: hexane/ethyl acetate=4/1 by volume) to obtain 1.73 g of 4-phenyl-3-buten-2-ol having a purity of 89%. {α}25 D : +18.1°(c=5, CS2).

Workup

  1. additionwere added
  2. customto react at 30° C. under a hydrogen pressure of 50 kg/cm2 for 45 hours
  3. customThe solvent was removed by distillation under reduced pressure (10 mmHg)
  4. customthe reaction product was analyzed by GLC (PEG HT, 25 m, produced by Gasukuro Kogyo K. K.)
  5. customThe product was separated into the unreacted ketone

Sources & evidence

ORD record
ord-ea4636c2ea984d078b6dc3a3f070d495
Source dataset
uspto-grants-1992_10
Patent number
US05159093

Reaction notes

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