Hydrochloric Acid → Alendronic Acid

HRID 467330

Reaction equation

HRID 467330 reaction equation
C1(=O)[N:5]([CH2:6][CH2:7][CH2:8][C:9]([P:17](=[O:22])([O:20]C)[O:18]C)([P:11](=[O:16])([O:14]C)[O:12]C)[OH:10])C(=O)C2=CC=CC=C12.Cl>>[NH2:5][CH2:6][CH2:7][CH2:8][C:9]([P:17](=[O:18])([OH:20])[OH:22])([P:11](=[O:12])([OH:14])[OH:16])[OH:10]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 9845824Tetramethyl phthalimido-1-hydroxybutylidene-bisphosphonate

Product 1

HCID 2088Alendronic Acid

Procedure

contacting tetramethyl phthalimido-1-hydroxybutylidene-bisphosphonate from Step (b) with aqueous hydrochloric acid at a temperature in the range of 80° C. to reflux to form 4-amino-1-hydroxybutylidene-bisphosphonic acid.

Workup

  1. customin the range of 80° C.
  2. temperatureto reflux

Sources & evidence

ORD record
ord-79a5b90cb2d34472b21ab1259fb3015e
Source dataset
uspto-grants-1992_10
Patent number
US05159108

Linked notes

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