Phenol → 4-Hydroxyphenylglycine

HRID 46943

Reaction equation

HRID 46943 reaction equation
[C:1]([O-:5])(=[O:4])[CH:2]=O.[NH4+:6].C([O-])(=O)C.[NH4+].[C:12]1([OH:18])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>O>[CH:14]1[C:15]([CH:2]([NH2:6])[C:1]([OH:5])=[O:4])=[CH:16][CH:17]=[C:12]([OH:18])[CH:13]=1

Participants

5

Reactant 3

HCID 996PhenolHCID 517165Ammonium AcetateHCID 20437102Ammonium glyoxylate

Product 1

HCID 921434-HydroxyphenylglycineYield 40.5%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

29.5 g of ammonium glyoxylate, 75 g of ammonium acetate, 60 g of phenol and 130 ml of water are treated in the same manner as described in Example 1. 21.9 g of DL-p-hydroxyphenylglycine are thereby obtained as crystals. Yield: 40.5%, M.p. 225°-228° C. (decomp.).

Sources & evidence

ORD record
ord-c605927454c2450b96b11c849caeabf7
Source dataset
uspto-grants-1979_11
Patent number
US04175206

Linked notes

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