Phenol → 4-Hydroxyphenylglycine
Reaction equation
[C:1]([O-:5])(=[O:4])[CH:2]=O.[Na+].C([O-])=O.[NH4+:10].[C:11]1([OH:17])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>O>[CH:13]1[C:14]([CH:2]([NH2:10])[C:1]([OH:5])=[O:4])=[CH:15][CH:16]=[C:11]([OH:17])[CH:12]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
36.9 g of sodium glyoxylate, 61.3 g of ammonium formate, 60 g of phenol and 130 g of water are treated in the same manner as described in Example 1. 18.5 g of DL-p-hydroxyphenylglycine are thereby obtained as crystals. Yield: 34.2% M.p. 225°-228° C. (decomp.).
Sources & evidence
- ORD record
- ord-6568d7eac24a4c50a34ceef5bb51d78a
- Source dataset
- uspto-grants-1979_11
- Patent number
- US04175206
Reaction notes
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