Ammonium Hydroxide → [2-(1-Methyl-pyrrolidin-yl)ethyl] thiourea

HRID 47274

Reaction equation

HRID 47274 reaction equation
[N:1]([CH2:4][CH2:5][CH:6]1[CH2:10][CH2:9][CH2:8][N:7]1[CH3:11])=[C:2]=[S:3].[OH-].[NH4+:13]>>[CH3:11][N:7]1[CH2:8][CH2:9][CH2:10][CH:6]1[CH2:5][CH2:4][NH:1][C:2]([NH2:13])=[S:3]

Participants

3

Reactant 2

HCID 14923Ammonium Hydroxide2×HCID 219923282-(2-Isothiocyanatoethyl)-1-methylpyrrolidine

Product 1

HCID 21992305[2-(1-Methyl-pyrrolidin-yl)ethyl] thiourea

Procedure

The 2-(2-isothiocyanatoethyl)-1-methylpyrrolidine and concentrated ammonium hydroxide (3 mL) were heated at 100° C. for 30 minutes. Additional ammonium hydroxide (1 mL) was added and heating was continued for an additional 30 minutes. The reaction mixture was allowed to cool to room temperature and then it was lyophilized to give [2-(1-methylpyrrolidin-2-yl)ethyl]thiourea as a very viscous colorless oil.

Workup

  1. temperatureheating

Sources & evidence

ORD record
ord-b966538370894aab817f4a3432f2391f
Source dataset
uspto-grants-2004_03
Patent number
US06699866B2

Linked notes

Loading…