Methyl iodide → 1-Methoxy-2-(trifluoromethyl)benzene
Reaction equation
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[OH:9].[C:12](=O)([O-])[O-].[K+].[K+].IC>CC(C)=O>[F:1][C:2]([F:10])([F:11])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[O:9][CH3:12]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of 10 g 2-trifluoromethyl phenol, 17 g potassium carbonate, 150 ml acetone and 7.7 ml iodomethane was heated under reflux for 2 hr. After cooling, the insoluble matters were removed by filtration, and the filtrate was evaporated. The resulting residue was dissolved in ethyl acetate, and washed with water and brine. It was dried over anhydrous magnesium sulfate, filtered, and evaporated to give 12.15 g of 2-trifluoromethyl anisole.
Workup
- temperaturewas heated
- temperatureunder reflux for 2 hr
- temperatureAfter cooling
- customthe insoluble matters were removed by filtration
- customthe filtrate was evaporated
- dissolutionThe resulting residue was dissolved in ethyl acetate
- washwashed with water and brine
- dry with materialIt was dried over anhydrous magnesium sulfate
- filtrationfiltered
- customevaporated
Sources & evidence
- ORD record
- ord-53767db6e48047baad2d6662a8734f6d
- Source dataset
- uspto-grants-2004_03
- Patent number
- US06699870B2
Reaction notes
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