Hydrochloric Acid → 4-Methoxy-3-(trifluoromethyl)benzylamine hydrochloride
Reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:6]([CH2:7][NH:8]C=O)=[CH:5][C:4]=1[C:13]([F:16])([F:15])[F:14].[ClH:17].C(OCC)C>C(O)C>[ClH:17].[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:6]([CH2:7][NH2:8])=[CH:5][C:4]=1[C:13]([F:14])([F:15])[F:16]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
3.8 g of N-[4-methoxy-3-(trifluoromethyl)benzyl]formamide was dissolved in 20 ml ethanol, 2 ml conc. hydrochloric acid was added thereto, and the mixture was heated under reflux for 3 hr. After cooling, diethyl ether was added thereto, and the resulting crystals were collected by filtration to give 2.5 g of 4-methoxy-3-(trifluoromethyl)benzylamine hydrochloride.
Workup
- temperaturethe mixture was heated
- temperatureunder reflux for 3 hr
- temperatureAfter cooling
- filtrationthe resulting crystals were collected by filtration
Sources & evidence
- ORD record
- ord-6d6291f394684e2fb7328e9ec108a50f
- Source dataset
- uspto-grants-2004_03
- Patent number
- US06699870B2
Reaction notes
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