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Cesium carbonate → (Rac)-trans-3-(3-(4-(pyridin-2-ylamino)phenoxy)pyrazin-2-yl)cyclohexanol

HRID 473690
Notes
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Reaction equation

HRID 473690 reaction equation
F[C:2]1[C:3]([C@H:8]2[CH2:13][CH2:12][CH2:11][C@H:10]([OH:14])[CH2:9]2)=[N:4][CH:5]=[CH:6][N:7]=1.[N:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[NH:21][C:22]1[CH:27]=[CH:26][C:25]([OH:28])=[CH:24][CH:23]=1.C(=O)([O-])[O-].[Cs+].[Cs+]>CN1C(=O)CCC1>[N:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[NH:21][C:22]1[CH:27]=[CH:26][C:25]([O:28][C:2]2[C:3]([C@H:8]3[CH2:13][CH2:12][CH2:11][C@H:10]([OH:14])[CH2:9]3)=[N:4][CH:5]=[CH:6][N:7]=2)=[CH:24][CH:23]=1
ParticipantsConditionsProcedureWorkupSources & evidenceReaction notes

Participants

5

Reactant 3

HCID 10796Cesium carbonateHCID 212625714-(Pyridin-2-ylamino)phenolHCID 59351407(Rac)-trans-3-(3-fluoropyrazin-2-yl)cyclohexanol

Product 1

HCID 59373952(Rac)-trans-3-(3-(4-(pyridin-2-ylamino)phenoxy)pyrazin-2-yl)cyclohexanol

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Conditions

Temperature
150 °C

Procedure

A mixture of (rac)-trans-3-(3-fluoropyrazin-2-yl)cyclohexanol (35 mg, 0.178 mmol), as prepared according to Scheme 35a, 4-(pyridin-2-ylamino)phenol (66.4 mg, 0.357 mmol), and cesium carbonate (116 mg, 0.357 mmol) in NMP (1 ml) was heated in a Biotage™ microwave reactor at 150° C. for 30 min. The mixture was partitioned between H2O (10 ml) and CH2Cl2 (20 ml), the layers were separated, and the aqueous layer was extracted with CH2Cl2 (3×20 ml). The combined organic layers were dried (MgSO4), concentrated under reduced pressure, and the resulting brown oil was purified by reversed phase HPLC (Gilson Gemini-NX 10u C18 110A, 100×50.0 mm, 10% to 95% H2O/MeCN, 0.1% TFA). The product containing fractions were combined, neutralized by the addition of solid Na2CO3, and extracted with CH2Cl2 (3×20 mL). The combined organic layers were dried (MgSO4) and concentrated under reduced pressure to deliver (rac)-trans-3-(3-(4-(pyridin-2-ylamino)phenoxy)pyrazin-2-yl)cyclohexanol as a tan solid. MS (ESI, pos. ion) m/z: 363.0(M+1). IC50 (uM) 0.01049.

Workup

  1. customas prepared
  2. customThe mixture was partitioned between H2O (10 ml) and CH2Cl2 (20 ml)
  3. customthe layers were separated
  4. extractionthe aqueous layer was extracted with CH2Cl2 (3×20 ml)
  5. dry with materialThe combined organic layers were dried (MgSO4)
  6. concentrationconcentrated under reduced pressure
  7. customthe resulting brown oil was purified by reversed phase HPLC (Gilson Gemini-NX 10u C18 110A, 100×50.0 mm, 10% to 95% H2O/MeCN, 0.1% TFA)
  8. additionThe product containing fractions
  9. additionneutralized by the addition of solid Na2CO3
  10. extractionextracted with CH2Cl2 (3×20 mL)
  11. dry with materialThe combined organic layers were dried (MgSO4)
  12. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-2b8606bfdd564d7a854522d61bc3a761
Source dataset
uspto-grants-2014_01
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US08637500B2

Reaction notes

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