HCID 86648151, compound → HCID 178518923, compound
Reaction equation
C(O)(=O)/C=C/C(O)=O.[Cl:9][C:10]1[N:15]=[N:14][C:13]([O:16]C(O)C)=[C:12]([N:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)[CH:11]=1>Br>[Cl:9][C:10]1[N:15]=[N:14][C:13]([OH:16])=[C:12]([N:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)[CH:11]=1Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
15 g (6-chloro-4-piperazin-1-yl-pyridazin-3-yloxy)-ethanol fumarate are suspended in 90 ml hydrobromic acid (48%). The reaction mixture is stirred for 1 hour at reflux temperature and evaporated to dryness. 19 g product are obtained as the hydrobromide. M.p=35° C.
Workup
- temperatureat reflux temperature
- customevaporated to dryness
Sources & evidence
- ORD record
- ord-57eb10a01bcd4cb189118240201c71e5
- Source dataset
- uspto-grants-2014_01
- Patent number
- US08637519B2
Reaction notes
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