Isopropanol → HCID 19838061, compound

Reaction equation

[OH:1][CH:2]1[NH:6][C:5](=[O:7])[CH:4]=[CH:3]1.[CH:8](O)([CH3:10])[CH3:9]>>[CH:8]([O:1][CH:2]1[NH:6][C:5](=[O:7])[CH:4]=[CH:3]1)([CH3:10])[CH3:9]

Participants

Reactant 2

HCID 3776Isopropanol

HCID 353549(R)-Dihydromaleimide

Product 1

HCID 19838061HCID 19838061, compound

Procedure

A mixture of 3 g of 1,5-dihydro-5-hydroxy-2H-pyrrol-2-one, 1.5 g of Amberlite IR 120 H and 60 cm3 of isopropanol is taken to 45°-50° C. for 3 hours. After cooling, filtering and evaporating to dryness, 1.8 g of the expected product is obtained, m.p. 79°-81° C., crystallized from isopropanol.

Workup

temperatureAfter cooling
filtrationfiltering
customevaporating to dryness

Sources & evidence

ORD record: ord-5adc35e61fc7448faeda8a9776ce27d9
Source dataset: uspto-grants-1989_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04885307

Reaction notes

Loading…