1-Hexanol → HCID 19838059, compound
Reaction equation
[OH:1][CH:2]1[NH:6][C:5](=[O:7])[CH:4]=[CH:3]1.[CH2:8](O)[CH2:9][CH2:10][CH2:11][CH2:12][CH3:13]>>[CH2:8]([O:1][CH:2]1[NH:6][C:5](=[O:7])[CH:4]=[CH:3]1)[CH2:9][CH2:10][CH2:11][CH2:12][CH3:13]Participants
3
Conditions
- Temperature
- 85 °C
Procedure
A mixture of 2.5 g of 1,5-dihydro-5-hydroxy-2H-pyrrol-2-one in 75 cm3 of 1-hexanol and 1.3 g of Amberlite IR 120 H is heated to 85° C. for 2 hours. After allowing to cool to ambient temperature, the resin is filtered off and the solvent is evaporated under reduced pressure. The residue is distilled, and 3.4 g of the expected product is obtained. b.p. 120°-125° C. under 0.4 mbar.
Workup
- temperatureto cool to ambient temperature
- filtrationthe resin is filtered off
- customthe solvent is evaporated under reduced pressure
- distillationThe residue is distilled
Sources & evidence
- ORD record
- ord-476efbf4b49e41cd86af0153b4677195
- Source dataset
- uspto-grants-1989_12
- Patent number
- US04885307
Reaction notes
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