Hydrochloric Acid → HCID 86743599, compound
Reaction equation
CN(C)[C:3](=[CH:9][CH:10]=[C:11]([CH2:17][CH2:18][CH2:19][CH3:20])[C:12]([O:14][CH2:15][CH3:16])=[O:13])[C:4]([O:6][CH2:7][CH3:8])=[S:5].Cl.C([OH:25])C>>[OH:25][C:3](=[CH:9][CH:10]=[C:11]([CH2:17][CH2:18][CH2:19][CH3:20])[C:12]([O:14][CH2:15][CH3:16])=[O:13])[C:4]([O:6][CH2:7][CH3:8])=[S:5]Participants
4
Conditions
- Temperature
- 20 °C
Procedure
The procedure is as in Example 2, starting with diethyl 2-dimethylamino-5-n-butylthio-2,4-hexadienedioate (10 g), 12N aqueous hydrochloric acid solution (63 cc) and ethanol (100 cc). The mixture is maintained for 1 hour at a temperature of approximately 20° C. After purification by chromatography on a silica column with dichloromethane as eluent, diethyl 2-hydroxy-5-n-butylthio-2,4-hexadienedioate (5.6 g), m.p. 37° C., is obtained. Diethyl 2-dimethylamino-5-n-butylthio-2,4-hexadienedioate may be prepared in the following manner: