Thiazole → HCID 70392285, compound
Reaction equation
[CH2:1]([CH:7]1[CH2:11][CH:10]=[CH:9][O:8]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[Cl:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][OH:19].[S:20]1[CH:24]=[CH:23][N:22]=[CH:21]1>>[Cl-:12].[CH2:1]([CH:7]1[CH2:11][CH2:10][CH:9]([O:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][C:21]2[S:20][CH:24]=[CH:23][NH+:22]=2)[O:8]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6]Participants
4
Procedure
Analogous to example 9 but starting from 2-hexyl-2,3-dihydrofuran and 6-chlorohexanol. Substitution of the chloro atom was performed with thiazole instead of pyridine in the same conditions but on a mixture of cis+trans isomers leading to the title compound as an highly hygroscopic compound.
Sources & evidence
- ORD record
- ord-0db2840020c14e75a9564c7bd69b8185
- Source dataset
- uspto-grants-1989_12
- DOI