Hydrochloric Acid → HCID 178499043, compound
Reaction equation
[NH2:1][C:2]1[N:6]=[C:5]([C:7]([O:9][CH3:10])=[O:8])[NH:4][N:3]=1.O=[C:12]([CH:19]([CH3:21])[CH3:20])[CH2:13][C:14](OCC)=[O:15].Cl>C(O)(=O)C>[OH:15][C:14]1[N:3]2[N:4]=[C:5]([C:7]([O:9][CH3:10])=[O:8])[N:6]=[C:2]2[N:1]=[C:12]([CH:19]([CH3:21])[CH3:20])[CH:13]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of 3-amino-5-methoxycarbonyl-s-triazole (60 g) and ethyl 3-oxo-4-methylvalerate (65 g) in 600 ml of acetic acid was refluxed for five hours, the reaction mixture was cooled to room temperature, its pH was lowered to 1 to 2 with concentrated hydrochloric acid, and the separated crystals were recrystallized from ethanol, affording 54 g of the objective compound as colorless crystals.
Workup
- temperaturewas refluxed for five hours
- customthe separated crystals were recrystallized from ethanol
Sources & evidence
- ORD record
- ord-1837fd41f4b841ae94cca38b944e622b
- Source dataset
- uspto-grants-1989_12
- Patent number
- US04888332
Reaction notes
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