Pyrrolidine → 2-(Pyrrolidin-1-ylmethyl)morpholine

Reaction equation

Cl[CH2:2][CH:3]1[O:8][CH2:7][CH2:6][N:5](CC2C=CC=CC=2)[CH2:4]1.[NH:16]1[CH2:20][CH2:19][CH2:18][CH2:17]1>>[N:16]1([CH2:2][CH:3]2[O:8][CH2:7][CH2:6][NH:5][CH2:4]2)[CH2:20][CH2:19][CH2:18][CH2:17]1

Participants

Reactant 2

HCID 31268Pyrrolidine

HCID 28015624-Benzyl-2-(chloromethyl)morpholine

Product 1

HCID 146275022-(Pyrrolidin-1-ylmethyl)morpholine

Procedure

By the use of 2-chloromethyl-4-benzylmorpholine and pyrrolidine, the reaction is similarly carried out as Reference example 2 to give 2-(1-pyrrolidinylmethyl)morpholine.

Sources & evidence

ORD record: ord-8e76f4b5c2fa44ed8f24aaf89895496a
Source dataset: uspto-grants-1989_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04889857

Reaction notes

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