HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → HCID 178509760, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-[4-(p-tert-Butylaminocarbonylphenyl)-4-hydroxy-n-butyl]-1-trimethylsilylimidazole | HCID 19930419 | — |
| Product | HCID 178509760 | HCID 178509760 | — |
Reaction Steps
A solution of 4.5 g of 4-[4-(p-tert-butylaminocarbonylphenyl)-4-hydroxy-n-butyl]-1-trimethylsilylimidazole in 50 ml of thionyl chloride is refluxed for 1 h, cooled and evaporated. The residue is partitioned between methylene chloride and aqueous sodium bicarbonate solution. The organic phase is separated, dried over sodium sulfate and evaporated to yield the title compound (c).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04889861 |
| Source dataset | uspto-grants-1989_12 |
| ORD ID | ord-5fbd31894475459982e5655955531d5c |
| Source note | uspto-grants-1989_12 |