3-(Chloromethyl)pyridine hydrochloride → 1-(Pyridin-3-ylmethyl)piperidin-4-one

Reaction equation

[NH:1]1[CH2:6][CH2:5][C:4](=[O:7])[CH2:3][CH2:2]1.Cl.[N:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15]Cl)[CH:10]=1>>[N:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][N:1]2[CH2:6][CH2:5][C:4](=[O:7])[CH2:3][CH2:2]2)[CH:10]=1

Participants

Reactant 2

HCID 233943-(Chloromethyl)pyridine hydrochloride

HCID 337214-Piperidone

Product 1

HCID 64216241-(Pyridin-3-ylmethyl)piperidin-4-one

Procedure

1-(3-Pyridinylmethyl)-4-piperidone is prepared from 4-piperidone and 3-picolyl chloride hydrochloride essentially as described above in Example 38, Scheme C, step a.

Sources & evidence

ORD record: ord-1532fc92196c472c882b2fca95be361b
Source dataset: uspto-grants-2003_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06642231B2

Reaction notes

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