p-Toluenesulfonic acid → N-[1-(1H-1,2,3-benzotriazol-1-yl)-2,2-dichloropropyl]-3,5-dichlorobenzamide

HRID 479549

Reaction equation

HRID 479549 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([Cl:11])[CH:10]=1)[C:5]([NH2:7])=[O:6].[Cl:12][C:13]([Cl:17])([CH3:16])[CH:14]=O.[NH:18]1[C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=2[N:20]=[N:19]1.C1(C)C=CC(S(O)(=O)=O)=CC=1>>[N:18]1([CH:14]([NH:7][C:5](=[O:6])[C:4]2[CH:3]=[C:2]([Cl:1])[CH:10]=[C:9]([Cl:11])[CH:8]=2)[C:13]([Cl:17])([Cl:12])[CH3:16])[C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=2[N:20]=[N:19]1

Participants

5

Reactant 4

HCID 6101p-Toluenesulfonic acidHCID 222893,5-DichlorobenzamideHCID 109754962,2-DichloropropanalHCID 178418385HCID 178418385, compound

Product 1

HCID 18770607N-[1-(1H-1,2,3-benzotriazol-1-yl)-2,2-dichloropropyl]-3,5-dichlorobenzamide

Procedure

A suspension of 3,5-dichlorobenzamide, 2,2-dichloropropionaldehyde, benzotriazole, and p-toluenesulfonic acid was processed as described in Example 53A to provide the desired product.

Sources & evidence

ORD record
ord-bb6e946167da43efacd08fe772824c8b
Source dataset
uspto-grants-2003_11
Patent number
US06645968B2

Linked notes

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