Hydrazine hydrate (1:1) → HCID 178434553, compound
Reaction equation
[F:1][C:2]([F:21])([F:20])[C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10](=[O:19])[C:11](=[CH:15]OCC)[C:12]([CH3:14])=O)=[CH:5][CH:4]=1.O.[NH2:23][NH2:24]>C(O)C>[CH3:14][C:12]1[C:11]([C:10]([NH:9][C:6]2[CH:7]=[CH:8][C:3]([C:2]([F:21])([F:20])[F:1])=[CH:4][CH:5]=2)=[O:19])=[CH:15][NH:24][N:23]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
N-[4-(Trifluoromethyl)phenyl]-2-(ethoxymethylene)-acetoacetamide (1 g) in 3 mL of ethanol is stirred overnight with 0.3 g of hydrazine hydrate. The precipitate is collected by vacuum filtration, washed with ethanol:water 2:1 and dried to give 0.3 g of 3-methyl-4-(4-(trifluoromethyl)phenylaminocarbonyl]pyrazole as an off-white solid.
Workup
- filtrationThe precipitate is collected by vacuum filtration
- washwashed with ethanol:water 2:1
- customdried
Sources & evidence
- ORD record
- ord-f0361f7d15f44be183fee3608191313b
- Source dataset
- uspto-grants-2003_11
- Patent number
- US06649635B2
Reaction notes
Loading…