Uridine → 5'-O-(4-Methylbenzoyl)uridine

HRID 48089

Reaction equation

HRID 48089 reaction equation
[CH3:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][CH:3]=1.[C@@H:11]1([N:20]2[CH:27]=[CH:26][C:24](=[O:25])[NH:23][C:21]2=[O:22])[O:19][C@H:16]([CH2:17][OH:18])[C@@H:14]([OH:15])[C@H:12]1[OH:13]>N1C=CC=CC=1>[CH3:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([O:18][CH2:17][C@H:16]2[O:19][C@@H:11]([N:20]3[CH:27]=[CH:26][C:24](=[O:25])[NH:23][C:21]3=[O:22])[C@H:12]([OH:13])[C@@H:14]2[OH:15])=[O:7])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6029UridineHCID 134054-Methylbenzoyl Chloride

Product 1

HCID 115885775'-O-(4-Methylbenzoyl)uridine

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

4-Methylbenzoyl chloride (10 mmol) is added to a solution of uridine (10 mmol) in 20 mL of pyridine. After no further progress occurs as observed by TLC, the volatile components are evaporated in vacuo. The residue is purified using flash chromatography to give the product as a colorless oil.

Workup

  1. customthe volatile components are evaporated in vacuo
  2. customThe residue is purified

Sources & evidence

ORD record
ord-5fea9a53770246ee989f9ac9adc592d9
Source dataset
uspto-grants-2004_03
Patent number
US06702705B1

Linked notes

Loading…