6-Nitroquinolin-5-ylamine → Quinoline-5,6-diamine
Reaction equation
[NH2:1][C:2]1[C:11]([N+:12]([O-])=O)=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[N:7]2>C1COCC1.CO.[Ni]>[NH2:1][C:2]1[C:11]([NH2:12])=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[N:7]2Participants
5
Reactant 1
Product 1
Reagents, catalysts & solvents 3
Procedure
A solution of 5-amino-6-nitroquinoline (25 g, 0.13 mol) in THF (500 mL) and methanol (500 mL) was treated with Raney nickel (7 g) under a hydrogen atmosphere (50.4 psi) on a Parr apparatus for 3.4 hours. Standard work-up gave the 5,6-diaminoquinoline.
Sources & evidence
- ORD record
- ord-7254d1bc18134c949e814f0cd113c64c
- Source dataset
- uspto-grants-2004_03
- Patent number
- US06703391B2
Reaction notes
Loading…