Hydrazine hydrate (1:1) → 3-Hydrazinyl-4-methyl-6-phenylpyridazine
Reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:6][C:7]=1[CH3:8].O.[NH2:16][NH2:17]>>[NH:16]([C:2]1[N:3]=[N:4][C:5]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:6][C:7]=1[CH3:8])[NH2:17]Participants
3
Procedure
The mixture of 5 g of 3-chloro 4-methyl 6-phenyl pyridazine and 12 ml of hydrazine hydrate is taken to reflux. After one hour thirty minutes, the reaction medium is left to cool. A solid separates, which is drained and washed with a little water. The product is recrystallized in the mixture of isopropanol-isopropyl ether. Weight 4.5 g. m.p.: 162° C.
Workup
- temperatureto reflux
- waitthe reaction medium is left
- temperatureto cool
- washwashed with a little water
- customThe product is recrystallized in the mixture of isopropanol-isopropyl ether
Sources & evidence
- ORD record
- ord-4dd22a27249b4a83aa0c79ad3126ee8d
- Source dataset
- uspto-grants-1986_03
- Patent number
- US04576946
Reaction notes
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