Ethyl 1-(p-chlorobenzyl)-5-chloro-3-thiophenylindole-2-carboxylate → 1-(p Chlorobenzyl)-5-chloro-3-thiophenylindole-2-carboxylic acid

HRID 483407

Reaction equation

HRID 483407 reaction equation
[Cl:1][C:2]1[CH:28]=[CH:27][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([Cl:16])=[CH:13][CH:14]=3)[C:9]([C:17]3[S:18][CH:19]=[CH:20][CH:21]=3)=[C:8]2[C:22]([O:24]CC)=[O:23])=[CH:4][CH:3]=1>O1CCCC1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([Cl:16])=[CH:13][CH:14]=3)[C:9]([C:17]3[S:18][CH:19]=[CH:20][CH:21]=3)=[C:8]2[C:22]([OH:24])=[O:23])=[CH:27][CH:28]=1

Participants

3

Reactant 1

HCID 67855865Ethyl 1-(p-chlorobenzyl)-5-chloro-3-thiophenylindole-2-carboxylate

Product 1

HCID 232009311-(p Chlorobenzyl)-5-chloro-3-thiophenylindole-2-carboxylic acid

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Following the procedure of Preparation 6, but using ethyl 1-(p-chlorobenzyl)-5-chloro-3-thiophenylindole-2-carboxylate from Example 1 as the starting material and tetrahydrofuran as the solvent, the title compound was prepared, mp 185°-188° (dec.).

Workup

  1. customthe procedure of Preparation 6

Sources & evidence

ORD record
ord-0e7fc3adaaa749b5ba36e059b32fa6e0
Source dataset
uspto-grants-1993_07
Patent number
US05225421

Linked notes

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