2-Chloro-4-nitropyridine 1-oxide → Pyridine, 2-chloro-4-methoxy-, 1-oxide

HRID 483758

Reaction equation

HRID 483758 reaction equation
[Na].[CH3:2][O-:3].[Na+].[Cl:5][C:6]1[CH:11]=[C:10]([N+]([O-])=O)[CH:9]=[CH:8][N+:7]=1[O-:15]>CO>[Cl:5][C:6]1[CH:11]=[C:10]([O:3][CH3:2])[CH:9]=[CH:8][N+:7]=1[O-:15]

Participants

5

Reactant 3

HCID 844332-Chloro-4-nitropyridine 1-oxideHCID 5360545SodiumHCID 10942334Sodium Methoxide

Product 1

HCID 15593755Pyridine, 2-chloro-4-methoxy-, 1-oxide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

Sodium (0.46 g) is dissolved in absolute methanol (50 ml) and the resultant solution of sodium methoxide is added to a solution of 2-chloro-4-nitropyridine-1-oxide (3.5 g, prepared as described in Example 1) in methanol (10 ml). The reaction mixture is allowed to stand at room temperature for 50 hours and is then subjected to rotary evaporation to give 2-chloro-4-methoxypyridine-1-oxide.

Workup

  1. customis then subjected to rotary evaporation

Sources & evidence

ORD record
ord-20eeab3c45f14020a6979e4c216e0572
Source dataset
uspto-grants-1993_07
Patent number
USRE034313

Linked notes

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