1,4-Dioxane hydrochloride → 2-Aminoindan-5-carboxylic acid morpholinamide hydrochloride

HRID 48435

Reaction equation

HRID 48435 reaction equation
[N:1]1([C:7]([NH2:9])=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.C(OC([NH:17][CH:18]1[CH2:26][C:25]2[C:20](=[CH:21][CH:22]=[C:23]([C:27]([OH:29])=[O:28])[CH:24]=2)[CH2:19]1)=O)(C)(C)C.[ClH:30].O1CCOCC1>C(O)(=O)C>[ClH:30].[N:1]1([C:7]([NH2:9])=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[NH2:17][CH:18]1[CH2:26][C:25]2[C:20](=[CH:21][CH:22]=[C:23]([C:27]([OH:29])=[O:28])[CH:24]=2)[CH2:19]1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 1317243662-(Tert-butoxycarbonylamino)indan-5-carboxylic acid morpholinamide

Product 1

HCID 698498462-Aminoindan-5-carboxylic acid morpholinamide hydrochloride

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Using 2-(tert-butoxycarbonylamino)indan-5-carboxylic acid morpholinamide (1.0 g, 2.7 mmol), 4N hydrochloric acid-dioxane (12 ml) and acetic acid (36 ml), a similar procedure to Production Example 213 was carried out to obtain 2-aminoindan-5-carboxylic acid morpholinamide hydrochloride (750 mg, 2.7 mmol) having the following physical properties:

Sources & evidence

ORD record
ord-fa21e3f9e6904a029afbc3594e1dbb39
Source dataset
uspto-grants-2004_03
Patent number
US06703421B1

Linked notes

Loading…