Formaldehyde → 2-Methoxymethyl-2-hydroxymethylbutanal

HRID 485691

Reaction equation

HRID 485691 reaction equation
C(N(CC)CC)C.[CH2:8]=[O:9].[CH2:10]([C:12](=[CH2:15])[CH:13]=[O:14])[CH3:11].[CH3:16][OH:17]>>[CH3:8][O:9][CH2:15][C:12]([CH2:13][OH:14])([CH2:10][CH3:11])[CH:16]=[O:17]

Participants

5

Reactant 4

HCID 712FormaldehydeHCID 887MethanolHCID 8471TriethylamineHCID 70203Ethylacrolein

Product 1

HCID 135045982-Methoxymethyl-2-hydroxymethylbutanal

Procedure

41 g of triethylamine are added to a mixture of 1600 ml of methanol, 500 g of 30% strength formaldehyde solution and 328 g of 2-ethylacrolein in the course of 10 minutes, and the solution is then kept at 78° C. for 7 hours. Low-boiling components are distilled off, after which 390 g (67%, based on 2-ethylacrolein) of the title compound of boiling point 95°-100° C./3 mbar are isolated by distillation under reduced pressure.

Workup

  1. distillationLow-boiling components are distilled off

Sources & evidence

ORD record
ord-ce2ab65782ed40c08a46eb9358eae7e5
Source dataset
uspto-grants-1985_08
Patent number
US04537901

Linked notes

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