Hydrochloric Acid → 4-(4-Dimethylaminobenzoylmethyl)piperidine dihydrochloride
Reaction equation
C([N:4]1[CH2:9][CH2:8][CH:7]([CH2:10][C:11](=[O:21])[C:12]2[CH:17]=[CH:16][C:15]([N:18]([CH3:20])[CH3:19])=[CH:14][CH:13]=2)[CH2:6][CH2:5]1)(=O)C.[ClH:22]>>[ClH:22].[ClH:22].[CH3:20][N:18]([CH3:19])[C:15]1[CH:14]=[CH:13][C:12]([C:11]([CH2:10][CH:7]2[CH2:8][CH2:9][NH:4][CH2:5][CH2:6]2)=[O:21])=[CH:17][CH:16]=1Participants
3
Conditions
- Temperature
- 100 °C
Procedure
In 30 mi of concentrated hydrochloric acid was dissolved 1.73 g of the 1-acetyl-4-(4-dimethylaminobenzoylmethyl)piperidine prepared in Example 39 and the mixture was stirred at 100° C. for 15 hours. The solvent was then distilled off and the residue was recrystallized from ethanol-ethyl acetate to give 1.7 g of colorless crystals melting at 251°-255° C.
Workup
- distillation