8-(3-Aminopropyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione → Theophylline
Reaction equation
NCCC[C:5]1[NH:14][C:13]2[C:12](=[O:15])[N:10]([CH3:11])[C:9](=[O:16])[N:8]([CH3:17])[C:7]=2[N:6]=1>C(=O)([O-])[O-]>[N:10]1([C:12](=[O:15])[C:13]2[NH:14][CH:5]=[N:6][C:7]=2[N:8]([CH3:17])[C:9]1=[O:16])[CH3:11]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 5 mM 8-(3-aminopropyl)-theophylline (R.C. Boguslaski et al., 1980) in 0.1 M carbonate buffer, pH 8.0, was incubated with an N-hydroxysuccinimide ester activated dextran surface (according to Example I.3.2) overnight at 25° C., whereupon the surface was washed with water.
Workup
- customdextran surface (according to Example I.3.2) overnight
- customat 25° C.
- washwhereupon the surface was washed with water
Sources & evidence
- ORD record
- ord-fef06120f7244b028a882a59eab365e0
- Source dataset
- uspto-grants-1993_09
- Patent number
- US05242828
Reaction notes
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