6-Bromohexanoic acid → HCID 178433620, compound
Reaction equation
[CH3:1][C:2]1[C:3]([CH3:12])([CH3:11])[C:4]2[C:5]([N:10]=1)=[N:6][CH:7]=[CH:8][CH:9]=2.[Br:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]([OH:21])=[O:20]>C(OCC)(=O)C>[Br-:13].[C:19]([CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][N:6]1[CH:7]=[CH:8][CH:9]=[C:4]2[C:3]([CH3:12])([CH3:11])[CH:2]([CH3:1])[NH+:10]=[C:5]12)([OH:21])=[O:20]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 120 °C
Procedure
A mixture of 0.54 g of 2,3,3-trimethyl-3H-pyrrolo[2,3-b]pyridine and 1.32 g of 6-bromohexanoic acid is heated at 120° C. for one hour. Ethyl acetate (10 mL) is added, and the reaction mixture is heated at reflux for 15 minutes, then cooled to room temperature. The supernatant liquid is decanted to yield the product.