1,3-Cyclopentanedicarboxylic anhydride → 3-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl]-3-azabicyclo[3.2.1]octane-2,4-dione

HRID 4918

Reaction equation

HRID 4918 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[CH2:11][CH2:10][N:9]([C:12]2[N:17]=[CH:16][CH:15]=[CH:14][N:13]=2)[CH2:8][CH2:7]1.[CH:18]12[CH2:25][CH:22]([CH2:23][CH2:24]1)[C:21](=[O:26])[O:20][C:19]2=O>>[N:17]1[CH:16]=[CH:15][CH:14]=[N:13][C:12]=1[N:9]1[CH2:8][CH2:7][N:6]([CH2:5][CH2:4][CH2:3][CH2:2][N:1]2[C:19](=[O:20])[CH:18]3[CH2:25][CH:22]([CH2:23][CH2:24]3)[C:21]2=[O:26])[CH2:11][CH2:10]1

Participants

3

Reactant 2

HCID 2397991,3-Cyclopentanedicarboxylic anhydrideHCID 128407054-(2-Pyrimidinyl)-1-piperazinebutanamine

Product 1

HCID 141563553-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl]-3-azabicyclo[3.2.1]octane-2,4-dioneYield 34%

Procedure

The title compound was prepared from 1.92 g (8.2 mmol) of 1-(4-aminobutyl)-4-(2-pyrimidinyl)piperazine and 1.14 g (8.14 mmol) of 3-oxabicyclo[3.2.1]octan-2,4-dione, substantially following the procedure of Example 1. Yield: 1.0 g (34% yield).

Sources & evidence

ORD record
ord-ff612c52e1a04b8e97b7f6d47d01eb91
Source dataset
uspto-grants-1993_09
Patent number
US05242911

Linked notes

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