1-Bromo-3-chloropropane → 1-(3-Chloropropyl)-4-methylpiperidin-4-ol

Reaction equation

[CH3:1][C:2]1([OH:8])[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.Br[CH2:10][CH2:11][CH2:12][Cl:13]>>[Cl:13][CH2:12][CH2:11][CH2:10][N:5]1[CH2:6][CH2:7][C:2]([CH3:1])([OH:8])[CH2:3][CH2:4]1

Participants

Reactant 2

HCID 80061-Bromo-3-chloropropane

HCID 156491744-Methylpiperidin-4-ol

Product 1

HCID 184498301-(3-Chloropropyl)-4-methylpiperidin-4-ol

Procedure

4-methylpiperidin-4-ol (made via literature methods) and 1-bromo-3-chloropropane are reacted using the procedure for Example OO to afford 1-(3-chloropropyl)-4-methylpiperidin-4-ol.

Sources & evidence

ORD record: ord-d8dcc986af294e0f9504b07fa450411c
Source dataset: uspto-grants-2009_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07531566B2

Reaction notes

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