Letrozole → HCID 178509721, compound

HRID 495062

Reaction equation

C1C(C#N)=CC=[C:3]([CH:9](N2N=CN=C2)[C:10]2[CH:11]=[CH:12][C:13]([C:16]#[N:17])=[CH:14][CH:15]=2)C=1.BrCC1C=CC(C#N)=CC=1.[NH:33]1[CH:37]=[N:36]C=[N:34]1>>[NH:33]1[CH:37]=[N:36][C:3]([CH2:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]#[N:17])=[CH:12][CH:11]=2)=[N:34]1

Participants

Reactant 3

HCID 3902Letrozole

HCID 92571H-1,2,4-Triazole

HCID 869964-(Bromomethyl)benzonitrile

Product 1

HCID 178509721HCID 178509721, compound

Procedure

U.S. Pat. No. 4,978,672 (“the '672 patent”) describes a process for preparing letrozole by reacting α-bromo-4-tolunitrile with 1,2,4-triazole to produce 4-[1-(1,2,4-triazolyl)methyl]-benzonitrile, and reacting the product with 4-fluorobenzonitrile to obtain letrozole.

Sources & evidence

ORD record: ord-7c41f7faad9440d2a073c3b280f93bd9
Source dataset: uspto-grants-2009_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07538230B2

Linked notes

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