Decanoyl chloride → 2-(decanoylamino)propanoic Acid

Reaction equation

Cl.[NH2:2][CH:3]([C:5]([O:7]C)=[O:6])[CH3:4].[C:9](Cl)(=[O:19])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]>>[C:9]([NH:2][CH:3]([CH3:4])[C:5]([OH:7])=[O:6])(=[O:19])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]

Participants

Reactant 2

HCID 66982Decanoyl chloride

HCID 2756298Alanine, methyl ester, hydrochloride (1:1)

Product 1

HCID 42026322-(decanoylamino)propanoic Acid

Procedure

The preparation is carried out analogously to the procedure of Example 7A using 19.0 g (184 mmol) of methyl D,L-alaninate hydrochloride and 35.14 g (184 mmol) of decanoyl chloride.

Sources & evidence

ORD record: ord-bec8ed5679a946fba20879e52c3204b6
Source dataset: uspto-grants-2005_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06943163B2

Reaction notes

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