1-Bromopropane → 2-Propoxybenzonitrile
Reaction equation
[OH:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5].C(=O)([O-])[O-].[K+].[K+].[CH3:16][CH2:17][CH2:18]Br>CC(C)=O>[CH2:16]([O:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5])[CH2:17][CH3:18]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
75 g (630 mmol) of 2-hydroxybenzonitrile, 174 g (1.26 mol) of potassium carbonate and 232.3 g (1.89 mol) of n-propyl bromide in 11 of acetone are refluxed overnight. The solid is filtered off, the solvent is removed under reduced pressure and the residue is distilled under reduced pressure.
Workup
- filtrationThe solid is filtered off
- customthe solvent is removed under reduced pressure
- distillationthe residue is distilled under reduced pressure
Sources & evidence
- ORD record
- ord-83fff3c8261e44a9b31116e95ad88a13
- Source dataset
- uspto-grants-2005_09
- Patent number
- US06943163B2
Reaction notes
Loading…