Sodium Hydroxide → 2-(Diphenylmethyl)-1-azabicyclo[2.2.2]octan-3-ol

Temperature

-65 °C

2-(Diphenylmethyl)-1-azabicyclo[2.2.2]octan-3-one (18.9 g) was dissolved in tetrahydrofuran (350 ml), anhydrous) and cooled to -65° C. under nitrogen. Lithium aluminium hydride (1.0 M solution in THF, 40 ml) was added dropwise to the solution which was stirred at room temperature overnight. Water (2 ml) followed by sodium hydroxide (15% 2 ml) and water (6 ml) were added dropwise to the solution resulting in precipitation of the inorganic salts. Magnesium sulfate (2 g) was added and the mixture filtered through celite. The solvent was removed in vacuo and the residue was recrystallised from isopropanol affording the pure cis isomer. The mother liquors were concentrated and found to be 80:20 cis/trans by 1H NMR; this was used in the examples without further purification.

1. additionwere added dropwise to the solution
2. customresulting in precipitation of the inorganic salts
3. filtrationthe mixture filtered through celite
4. customThe solvent was removed in vacuo
5. customthe residue was recrystallised from isopropanol affording the pure cis isomer
6. concentrationThe mother liquors were concentrated

ORD record

ord-520e0e99ffeb4242aef88c01c7045ec3

Source dataset

uspto-grants-1993_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05242930