Methyl Decanoate → Decanohydrazide

HRID 49741

Reaction equation

HRID 49741 reaction equation
C[O:2][C:3](=O)[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].O.[NH2:15][NH2:16]>C(O)C>[C:3]([NH:15][NH2:16])(=[O:2])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12]

Participants

4

Reactant 2

HCID 8050Methyl DecanoateHCID 24654Hydrazine hydrate (1:1)

Product 1

HCID 98597DecanohydrazideYield 94%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

17.5 g of decanoic acid methyl ester is dissolved in 1 l of absolute ethanol and mixed with 350 ml of hydrazine hydrate. It is refluxed for 3 hours and then stirred overnight at room temperature. The solution is concentrated by evaporation to about 300 ml and allowed to stand until the product is crystallized out. After it is filtered off and dried, 16.6 g (=94% of theory) of decanoic acid hydrazide is obtained.

Workup

  1. temperatureIt is refluxed for 3 hours
  2. concentrationThe solution is concentrated by evaporation to about 300 ml
  3. customis crystallized out
  4. filtrationAfter it is filtered off
  5. customdried

Sources & evidence

ORD record
ord-d63e462b8fd14c8bbc6a3c4b6aae5b72
Source dataset
uspto-grants-2004_03
Patent number
US06709693B1

Linked notes

Loading…