Water → 4-Acetyl-n-(3-(1-acetylpiperazin-4-yl)phenyl)-2-nitroaniline

HRID 49816

Reaction equation

HRID 49816 reaction equation
[CH3:1][C:2]([C:4]1[CH:9]=[CH:8][C:7](F)=[C:6]([N+:11]([O-:13])=[O:12])[CH:5]=1)=[O:3].[C:14]([N:17]1[CH2:22][CH2:21][N:20]([C:23]2[CH:24]=[C:25]([CH:27]=[CH:28][CH:29]=2)[NH2:26])[CH2:19][CH2:18]1)(=[O:16])[CH3:15].O>CN1C(=O)CCC1>[C:2]([C:4]1[CH:9]=[CH:8][C:7]([NH:26][C:25]2[CH:27]=[CH:28][CH:29]=[C:23]([N:20]3[CH2:19][CH2:18][N:17]([C:14](=[O:16])[CH3:15])[CH2:22][CH2:21]3)[CH:24]=2)=[C:6]([N+:11]([O-:13])=[O:12])[CH:5]=1)(=[O:3])[CH3:1]

Participants

5

Reactant 3

HCID 962WaterHCID 27346124'-Fluoro-3'-nitroacetophenoneHCID 111175391-[4-(3-Aminophenyl)piperazin-1-yl]ethan-1-one

Product 1

HCID 223302264-Acetyl-n-(3-(1-acetylpiperazin-4-yl)phenyl)-2-nitroaniline

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of 1b (0.75 g, 4.1 mmol) and 2d (0.9 g, 4.1 mmol) in anhydrous NMP (2 ml) was heated to 80° C. overnight under a stream of nitrogen. After cooling water (20 ml) was added and the mixture was extracted with dichloromethane. The organic extract was dried over sodium sulfate and the solvent was removed under reduced pressure. The residue was purified by column-chromatography on silica gel using ethyl acetate as the eluent to yield 4-acetyl-N-(3-(1-acetylpiperazin-4-yl)phenyl)-2-nitroaniline as an oil.

Workup

  1. additionwas added
  2. extractionthe mixture was extracted with dichloromethane
  3. extractionThe organic extract
  4. dry with materialwas dried over sodium sulfate
  5. customthe solvent was removed under reduced pressure
  6. customThe residue was purified by column-chromatography on silica gel

Sources & evidence

ORD record
ord-da6a3f7e113d4c7caef77cfec8bc0628
Source dataset
uspto-grants-2004_03
Patent number
US06710044B2

Linked notes

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