Hydrochloric Acid → 6-Quinolinecarboxylic acid, ethyl ester

HRID 49926

Reaction equation

HRID 49926 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([OH:13])=[O:12])=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.O1CCO[CH2:16][CH2:15]1.Cl>C(O)C>[N:1]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([O:13][CH2:15][CH3:16])=[O:12])=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 825716-Quinolinecarboxylic acid

Product 1

HCID 946706-Quinolinecarboxylic acid, ethyl ester

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
70 °C

Procedure

4.9 g of quinoline-6-carboxylic acid was stirred in 80 ml of ethanol. 40 ml of dioxane containing 4 M of hydrogen chloride was added to the obtained mixture. After stirring at 70° C. overnight, the solvent was evaporated and the residue was treated with ethyl acetate as the extracting solvent by an ordinary method to obtain the title compound.

Workup

  1. customthe solvent was evaporated
  2. additionthe residue was treated with ethyl acetate as the extracting solvent by an ordinary method

Sources & evidence

ORD record
ord-39bdd5917a824cf489af4d15fa464529
Source dataset
uspto-grants-2004_03
Patent number
US06710056B2

Linked notes

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