Hydrochloric Acid → Ethyl 5-nitrothiophene-2-carboxylate

HRID 49931

Reaction equation

HRID 49931 reaction equation
[N+:1]([C:4]1[S:8][C:7]([C:9]([OH:11])=[O:10])=[CH:6][CH:5]=1)([O-:3])=[O:2].O1CCO[CH2:14][CH2:13]1.Cl>C(O)C>[N+:1]([C:4]1[S:8][C:7]([C:9]([O:11][CH2:13][CH3:14])=[O:10])=[CH:6][CH:5]=1)([O-:3])=[O:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 805915-Nitro-2-thenoic acid

Product 1

HCID 304627Ethyl 5-nitrothiophene-2-carboxylate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
60 °C

Procedure

5 g of 5-nitrothiophene-2-carboxylic acid was stirred in 100 ml of ethanol. 20 ml of dioxane containing 4 M of hydrogen chloride was added to the obtained mixture, and they were stirred at 60° C. for 2 days. The solvent was evaporated to obtain the title compound.

Workup

  1. customThe solvent was evaporated

Sources & evidence

ORD record
ord-f84d5a426a894c01af94fb8ebc136096
Source dataset
uspto-grants-2004_03
Patent number
US06710056B2

Linked notes

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