Hydrochloric Acid → Ethyl 5-nitrothiophene-2-carboxylate
Reaction equation
[N+:1]([C:4]1[S:8][C:7]([C:9]([OH:11])=[O:10])=[CH:6][CH:5]=1)([O-:3])=[O:2].O1CCO[CH2:14][CH2:13]1.Cl>C(O)C>[N+:1]([C:4]1[S:8][C:7]([C:9]([O:11][CH2:13][CH3:14])=[O:10])=[CH:6][CH:5]=1)([O-:3])=[O:2]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 60 °C
Procedure
5 g of 5-nitrothiophene-2-carboxylic acid was stirred in 100 ml of ethanol. 20 ml of dioxane containing 4 M of hydrogen chloride was added to the obtained mixture, and they were stirred at 60° C. for 2 days. The solvent was evaporated to obtain the title compound.
Workup
- customThe solvent was evaporated
Sources & evidence
- ORD record
- ord-f84d5a426a894c01af94fb8ebc136096
- Source dataset
- uspto-grants-2004_03
- Patent number
- US06710056B2
Reaction notes
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