Methylamine → 3-Hydroxy-N-methyl-5-(trifluoromethyl)benzamide

Reaction equation

[OH:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:10]=1)[C:5](O)=[O:6].[CH3:15][NH2:16]>>[OH:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:10]=1)[C:5]([NH:16][CH3:15])=[O:6]

Participants

Reactant 2

HCID 6329Methylamine

HCID 27831463-hydroxy-5-(trifluoromethyl)benzoic Acid

Product 1

HCID 674156453-Hydroxy-N-methyl-5-(trifluoromethyl)benzamide

Procedure

Prepared from 3-hydroxy-5-(trifluoromethyl)benzoic acid and methylamine using the method of preparation 58 to give the title compound as a pale orange solid.

Workup

customthe method of preparation 58

Sources & evidence

ORD record: ord-1e1c171148c04980b2b3b723cf0217f1
Source dataset: uspto-grants-2010_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07767715B2

Reaction notes

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